The effects of drug load and operational variables on formulations derived from these four lactose types were evaluated for physicochemical and mechanical attributes of plugs and their capsules on an instrumented dosing-disc capsule filling machine (H&H KFM/3) using acetaminophen as a model, highly soluble and poorly compressible drug.
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This study aimed to explore the capabilities of UV/VIS-based machine vision in tablet inspection as a PAT tool for the determination of compression force and crushing strength, drug content and drug distribution in tablets using meloxicam a yellow model drug.
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1. Introduction. In the pharmaceutical industry, assuring that the patient receives a treatment of the specified quality is of utmost importance. This became especially relevant with the release of U.S. Food and Drug Administration (FDA)’s Process Analytical Technology (PAT) initiative (Food and Drug Administration, 2004; Pomerantsev and Rodionova, 2012), as this document encourages
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